Research in the areas of both manufacturing and marketing/sales have advocated the integration of several important interrelated decisions between the two functions. The process of managing the strategic alignment between a firm's business strategy, external environment, and the integration of manufacturing and marketing/sales decisions is very complex phenomenon that requires a level of analysis that has not occurred previously. This study examined the moderating effects of business strategy and demand uncertainty on the relationship between the integartion of manufacturing and marketing/sales based decisions and orginzational performance. The study found general support for the proposed model, suggesting that the impact of the integration of manufacturing and marketing/sales decision on organizational performance is moderated by firm's business strategy and demand uncertainty.