Small and Medium Enterprises (SMEs) are the backbone of the Indonesian economic condition. Indonesia must boost the SME sector that has proved reliable in the conditions of economic crisis. A business phenomenon today is the increasing globalization of the world economic, requires all businesses including SMEs aware for the growing of markets opportunity. In fact, many SMEs are not able to even fail to penetrate the global market opportunities. As a result, SMEs are required to leave the practice in traditional trading strategies and tactics, and move to implement the innovative management by finding the new ways and unique to be able to compete more effectively both at local, regional and global. The purpose of this research is to build a model for development of SMEs strategy to expand the global market. The advances in technology, computers, and telecommunications was the potential tools to support the development of internet technology. Recently, internet users are increase that an opportunities for SMEs to change its marketing strategy with e-Marketing Mix and e-CRM in order to always be able to produce innovative products through customer value co-creation.